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Doctors choose hydroxocobalamin based on the patients needs and how they react to treatment
Andersson, Emmanuel Shapira, Biochemical and clinical response to hydroxocobalamin versus cyanocobalamin treatment in patients with methylmalonic acidemia and homocystinuria (cblC), The Journal of Pediatrics, Volume 132, Issue 1, January 1998, Pages 121-124, ISSN 0022-3476, Gimsing P, Hippe E, Helleberg-Rasmussen I, et al
Body weight-based dosing around 4-6mcg per kilogram provides individualized starting points
The biggest difference is bioavailability , which is how much of the vitamin enters your bloodstream
This is called the initial loading phase
What it is / mechanism 5-Amino-1MQ is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide (consuming the methyl donor SAM) to form 1-methylnicotinamide, diverting nicotinamide away from the NAD+ salvage pathway
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